RISCTOX Database

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Identification

Name:
maleic anhydride
Synonyms:
  • ANHIDRIDO MALEICO, MONOESTER CON NONILFENOL ETOXILADO, NEUTRALIZADO CON PRODUCTOS DE REACCION COMO DIPROPILEN-TRIAMINA
CAS:
108-31-6
EC/EINECS:
203-571-6
Molecular Formula:
C4H2O3
International Chemical Safety Card (ICSC):
0799

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS05

    Corrosive to metals

  • GHS07

    Acute toxicity (oral, dermal, inhalation

  • GHS08

    Respiratory sensitisation

H Phrases

  • H302 : Harmful if swallowed

    Acute Tox. (Cat. 4 *) : Acute toxicity

  • H314 : Causes severe skin burns and eye damage

    Skin Corr. (Cat. 1B) : Skin corrosion/irritation

  • H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled

    Resp. Sens. (Cat. 1) : Respiratory/skin sensitization

  • H317 : May cause an allergic skin reaction

    Skin Sens. (Cat. 1) : Respiratory/skin sensitization

Specific health risks

As per IARC ?

Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

IARC Group
IARC Volume
IARC Notes
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As per other sources

List generated from dn_risc_sustancias_cancer_otras

Category
G-A4
Source
ACGIH
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Endocrine disruptors ?

Substances with endocrine disrupting activity

Disruptor level
UE2
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Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

OEL Data
List
Sensitisers ?

Substances with skin or respiratory sensitisation potential

List

Specific environmental risks

Aquatic toxicity (Water Framework Directive) ?

Substances classified with acute aquatic toxicity under the CLP Regulation (H400 phrase, Aquatic Acute 1). They present an immediate hazard to aquatic organisms, and their use or discharge can cause rapid damage to aquatic ecosystems.

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Atmospheric emissions ?

Substances subject to atmospheric emission limitations under the Industrial Emissions Directive (2010/75/EU) and its Spanish transposition. Includes pollutants regulated in industrial installation emission permits and best available technique reference documents (BAT/BREF).

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Environmental regulations

LPCIC (EPER)

Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).

EPER Water
1
EPER Air
EPER Soil
1
List
EPER Water ?

Substances from List 1 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Atmospheric pollutants —including SO₂, NOx, heavy metals and organic compounds— that must be taken into account when setting emission limit values for IPPC installations.

EPER Water
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EPER Soil ?

Substances from List 3 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Substances present in waste generated by IPPC installations that must be controlled and minimised within the framework of best available techniques.

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Restriction/prohibition regulations

Substances under evaluation. CoRAP ?

Substances included in the Community Rolling Action Plan (CoRAP) of the REACH Regulation. These are substances selected for evaluation by EU Member States due to indications of risk to human health or the environment, with the aim of clarifying whether regulatory action is warranted.

Year
2013
Member State
Austria
Initial grounds for concern
Human health/Sensitiser; Exposure/High RCR; Aggregated tonnage
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Substances under evaluation. PACT ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State
Activity
Last update
Scope
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REACH sensitisers ?

Substances identified as respiratory or skin sensitisers under the REACH Regulation. Includes substances that, without necessarily having a CLP classification, have been assessed by ECHA as potentially allergenic in occupational exposure contexts.

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