Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

Substances with endocrine disrupting activity

Substances classified as toxic for reproduction under Regulation 1272/2008

Substances identified as Persistent, Bioaccumulative and Toxic (PBT) according to the criteria of Annex XIII of the REACH Regulation. They pose a special risk of accumulation in the environment and in the food chain.

Substances classified with acute aquatic toxicity under the CLP Regulation (H400 phrase, Aquatic Acute 1). They present an immediate hazard to aquatic organisms, and their use or discharge can cause rapid damage to aquatic ecosystems.

Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).

Substances from List 1 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Atmospheric pollutants —including SO₂, NOx, heavy metals and organic compounds— that must be taken into account when setting emission limit values for IPPC installations.

Substances from List 3 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Substances present in waste generated by IPPC installations that must be controlled and minimised within the framework of best available techniques.

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

Substances included in the Community Rolling Action Plan (CoRAP) of the REACH Regulation. These are substances selected for evaluation by EU Member States due to indications of risk to human health or the environment, with the aim of clarifying whether regulatory action is warranted.

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.