RISCTOX

RISCTOX Database

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Identification

Name:
4,4'-methylenedicyclohexyl diisocyanate
Name (English):
4,4'-methylenedicyclohexyl diisocyanate
Synonyms:
  • METILENO-bis(4-CICLOHEXILISOCIANATO)
  • DIISOCIANATO DE 4,4'-METILENDICICLOHEXIL
  • DIISOCIANATO DE 4,4'-DICICLOHEXILMETANO
CAS:
5124-30-1
EC/EINECS:
225-863-2
Molecular Formula:
C15H22N2O2

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS06

    Acute toxicity (oral, dermal, inhalation)

  • GHS08

    Respiratory sensitisation

H Phrases

  • H331 : Toxic if inhaled

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H319 : Causes serious eye irritation

    Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation

  • H335 : May cause respiratory irritation

    STOT SE (Cat. 3) : Specific target organ toxicity - single exposure

  • H315 : Causes skin irritation

    Skin Irrit. (Cat. 2) : Skin corrosion/irritation

  • H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled

    Resp. Sens. (Cat. 1) : Respiratory/skin sensitization

  • H317 : May cause an allergic skin reaction

    Skin Sens. (Cat. 1) : Respiratory/skin sensitization

Notes

  • R.1272-Note 2
Labelling
Concentration Labelling
*
C >= 0,5 % Sens. resp., 1; H334
C >= 0,5 % Sens. cut., 1; H317

Specific health risks

Endocrine disruptors ?

Substances with endocrine disrupting activity

Disruptor level
NS
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Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

OEL Data
—
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Sensitisers ?

Substances with skin or respiratory sensitisation potential

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Specific environmental risks

Hazardous water substances (Germany) ?

Substances classified with chronic aquatic toxicity under the CLP Regulation (H410–H413 phrases, Aquatic Chronic categories 1 to 4). They pose a long-term hazard to aquatic organisms, even at low concentrations and through prolonged exposure.

MMA Classification
1
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Environmental regulations

Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

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Restriction/prohibition regulations

Substances under evaluation. PACT ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State
Germany
Activity
RMOA
Last update
2014-09-23T00:00:00
Scope
Sensitiser
List
REACH sensitisers ?

Substances identified as respiratory or skin sensitisers under the REACH Regulation. Includes substances that, without necessarily having a CLP classification, have been assessed by ECHA as potentially allergenic in occupational exposure contexts.

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