Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

Substances with endocrine disrupting activity

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

Substances identified as Persistent, Bioaccumulative and Toxic (PBT) according to the criteria of Annex XIII of the REACH Regulation. They pose a special risk of accumulation in the environment and in the food chain.

Substances classified with acute aquatic toxicity under the CLP Regulation (H400 phrase, Aquatic Acute 1). They present an immediate hazard to aquatic organisms, and their use or discharge can cause rapid damage to aquatic ecosystems.

Substances classified with chronic aquatic toxicity under the CLP Regulation (H410–H413 phrases, Aquatic Chronic categories 1 to 4). They pose a long-term hazard to aquatic organisms, even at low concentrations and through prolonged exposure.

Substances subject to atmospheric emission limitations under the Industrial Emissions Directive (2010/75/EU) and its Spanish transposition. Includes pollutants regulated in industrial installation emission permits and best available technique reference documents (BAT/BREF).

Substances identified as soil contaminants under Spanish and European environmental regulations. Includes substances capable of persisting in soil, bioaccumulating in the terrestrial food chain, and affecting soil ecosystems and groundwater.

Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).

Substances from List 2 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Pollutants that may affect surface and groundwater bodies and must be considered in the integrated environmental authorisation of industrial installations.

Substances from List 3 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Substances present in waste generated by IPPC installations that must be controlled and minimised within the framework of best available techniques.

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).