RISCTOX

RISCTOX Database

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Identification

Name:
1,4-dioxane
Synonyms:
  • dioxido de etileno
  • dioxano
CAS:
123-91-1
EC/EINECS:
204-661-8
Molecular Formula:
C4H8O2
International Chemical Safety Card (ICSC):
0041
Uses:
solvent

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS02

    Flammable gases

  • GHS07

    Acute toxicity (oral, dermal, inhalation

  • GHS08

    Respiratory sensitisation

H Phrases

  • H225 : Highly flammable liquid and vapour

    Flam. Liq. (Cat. 2) : Flammable liquid

  • H351 : Suspected of causing cancer

    Carc. (Cat. 2) : Carcinogenicity

  • H319 : Causes serious eye irritation

    Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation

  • H335 : May cause respiratory irritation

    STOT SE (Cat. 3) : Specific target organ toxicity - single exposure

  • EUH019

  • EUH066

Notes

  • R.1272-Note D

Specific health risks

As per IARC ?

Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

IARC Group
GRUPO 2B
IARC Volume
(VOL. 11, SUPL. 7, VOL. 71; 1999)
IARC Notes
—
List
As per other sources

List generated from dn_risc_sustancias_cancer_otras

Category
G-A3, N-2, CP
Source
ACGIH, NTP, CP65
List
Carcinogens and mutagens (IARC) ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group
Grupo 2B
IARC Volume
(VOL. 11, SUPL. 7, VOL. 71; 1999)
IARC Notes
—
List
Carcinogens (other sources) ?

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Category
G-A3, N-2, CP
Source
ACGIH, NTP, CP65
List
Breast cancer ?

Substances classified with H362 phrase (may cause harm to breast-fed children). Toxic for reproduction due to effects on lactation or due to transmissibility through breast milk.

Source
http://sciencereview.silentspring.org/mamm_detail.cfm?cid=123-91-1
List
Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect
—
Level
2
Source
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List
Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

OEL Data
—
List
Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

List

Environmental regulations

Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

List

Restriction/prohibition regulations

Substances under evaluation. PACT ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State
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Activity
—
Last update
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Scope
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List