RISCTOX Database

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Identification

Name:
m-phenylenediamine
Synonyms:
  • meta-FENILENDIAMINA
  • meta-FENILENODIAMINA
CAS:
108-45-2
EC/EINECS:
203-584-7
Molecular Formula:
C6H8N2
International Chemical Safety Card (ICSC):
1302
Uses:
stabilizer

Black list

Substances particularly hazardous to the environment or health

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS06

    Acute toxicity (oral, dermal, inhalation)

  • GHS08

    Respiratory sensitisation

  • GHS09

    Hazardous to the aquatic environment

H Phrases

  • H341 : Suspected of causing genetic defects

    Muta. (Cat. 2) : Germ cell mutagenicity

  • H331 : Toxic if inhaled

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H311 : Toxic in contact with skin

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H301 : Toxic if swallowed

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H319 : Causes serious eye irritation

    Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation

  • H317 : May cause an allergic skin reaction

    Skin Sens. (Cat. 1) : Respiratory/skin sensitization

  • H400 : Very toxic to aquatic life

    Aquatic Acute (Cat. 1) : Hazardous to the aquatic environment

  • H410 : Very toxic to aquatic life with long lasting effects

    Aquatic Chronic (Cat. 1) : Hazardous to the aquatic environment

Specific health risks

As per IARC ?

Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

IARC Group
Grupo 3
IARC Volume
(VOL. 16, SUPL. 7; 1987)
IARC Notes
List
Carcinogens and mutagens (IARC) ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group
Grupo 3
IARC Volume
(VOL. 16, SUPL. 7; 1987)
IARC Notes
List
Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

OEL Data
List
Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

List
Sensitisers ?

Substances with skin or respiratory sensitisation potential

List

Environmental regulations

Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

List

Restriction/prohibition regulations

Substances under evaluation. CoRAP ?

Substances included in the Community Rolling Action Plan (CoRAP) of the REACH Regulation. These are substances selected for evaluation by EU Member States due to indications of risk to human health or the environment, with the aim of clarifying whether regulatory action is warranted.

Year
2018
Member State
Latvia
Initial grounds for concern
Suspected Reprotoxic; Sensitiser; Exposure of workers; High (aggregated) tonnage
List
Substances under evaluation. PACT ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State
Activity
Last update
Scope
List