RISCTOX

RISCTOX Database

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4,4'-methylenediphenyl diisocyanate, diphenylmethane-4,4'-diisocyanate@2,2'-methylenediphenyl diisocyanate@ Diphenylmethane-2,2'-diisocyanate@ o-(p-isocyanatobenzyl)phenyl isocyanate@Diphenylmethane-2,4'-diisocyanate@Methylenediphenyl diisocyanate@ MDI@ 4,4´-MDI

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Name

4,4'-methylenediphenyl diisocyanate, diphenylmethane-4,4'-diisocyanate@2,2'-methylenediphenyl diisocyanate@ Diphenylmethane-2,2'-diisocyanate@ o-(p-isocyanatobenzyl)phenyl isocyanate@Diphenylmethane-2,4'-diisocyanate@Methylenediphenyl diisocyanate@ MDI@ 4,4´-MDI

Identification Numbers

  • CAS: 101-68-8
  • EC/EINECS: 202-966-0
  • International Chemical Safety Card (ICSC): 0298

More information

  • Molecular Formula: C15H10N2O2
  • Synonyms: 4,4'-diisocianato de difenilmetano, 4,4´-metilen-bis-fenil isocianato, diisocianato de difenilmetano, 4,4'-metilenodifenil diisocianato, metileno difenileno diisocianato, diisocianato de 2,2'-metilendifenilo, diisocianato de 2,2'-difenilmetano, diisocianato de metilendifenilo, diisocianato de 2,4'-difenilmetano, isocianato de o-(p-isocianatobencil)fenilo

CLASSIFICATION (RD 363/1995)

Number Classification
1 Carc. Cat. 3; R40
2 Xn; R20-48/20
3 Xi; R36/37/38
4 R42/43

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Number Classification
1 Carc., 2; H351
2 Tox. ag., 4 *; H332
3 STOT repe., 2 *; H373**
4 Irrit. oc., 2; H319
5 STOT única, 3; H335
6 Irrit. cut., 2; H315
7 Sens. resp., 1; H334
8 Sens. cut., 1; H317

Symbols

  • Xn

    Xn

    Harmful

Notes

Lists

IARC List

List generated from legacy_dn_risc_sustancias_iarc

List
IARC Group
Grupo 3
IARC Volume
(VOL. 19, SUPL. 7, VOL. 71; 1999)
IARC Notes
—

Substances under evaluation. CoRAP

List generated from legacy_ist_risc_sustancias_corap

List
Year
2013
Member State
Estonia
Initial grounds for concern
Human health/CMR; Sensitiser; Environment/Suspected PBT; Exposure/Wide dispersive use; Consumer use; Aggregated tonnage

Substances under evaluation. PACT

List generated from ist_risc_sustancias_pact

List
Member State
Estonia
Activity
Hazard assessment
Last update
2019-01-28T00:00:00
Scope
PBT

Restricted substances REACH

List generated from legacy_dn_risc_sustancias_restringidas

List
Notes

Limitations: 1. Shall not be placed on the market after 27 December 2010, as a constituent of mixtures in concentrations equal to or greater than 0,1 % by weight of MDI for supply to the general public, unless suppliers shall ensure before the placing on the market that the packaging: (a) contains protective gloves which comply with the requirements of Council Directive 89/686/EEC (*******); (b) is marked visibly, legibly and indelibly as follows, and without prejudice to other Community legislation concerning the classification, packaging and labelling of substances and mixtures: ‘— Persons already sensitised to diisocyanates may develop allergic reactions when using this product. — Persons suffering from asthma, eczema or skin problems should avoid contact, including dermal contact, with this product. — This product should not be used under conditions of poor ventilation unless a protective mask with an appropriate gas filter (i.e. type A1 according to standard EN 14387) is used.’ 2. By way of derogation, paragraph 1(a) shall not apply to hot melt adhesives. (*******) OJ L 399, 30.12.1989, p. 18.

Source: Regulation 1907/2006 (REACH). Annex XVII