RISCTOX

RISCTOX Database

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Identification

Name:
GLYCIDOL@2,3-epoxypropan-1-ol
Synonyms:
  • 2,3-EPOXI-1-PROPANOL
  • GLICIDOL
  • 2,3-EPOXI-1-PROPANOLGLICIDOL
CAS:
556-52-5
EC/EINECS:
209-128-3
Molecular Formula:
C3H6O2
International Chemical Safety Card (ICSC):
0159

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS06

    Acute toxicity (oral, dermal, inhalation)

  • GHS08

    Respiratory sensitisation

H Phrases

  • H350 : May cause cancer

    Carc. (Cat. 1B) : Carcinogenicity

  • H341 : Suspected of causing genetic defects

    Muta. (Cat. 2) : Germ cell mutagenicity

  • H360F *** : May damage fertility.

    Repr. (Cat. 1B) : Reproductive toxicity

  • H331 : Toxic if inhaled

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H312 : Harmful in contact with skin

    Acute Tox. (Cat. 4 *) : Acute toxicity

  • H302 : Harmful if swallowed

    Acute Tox. (Cat. 4 *) : Acute toxicity

  • H319 : Causes serious eye irritation

    Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation

  • H335 : May cause respiratory irritation

    STOT SE (Cat. 3) : Specific target organ toxicity - single exposure

  • H315 : Causes skin irritation

    Skin Irrit. (Cat. 2) : Skin corrosion/irritation

Specific health risks

As per IARC ?

Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

IARC Group
GRUPO 2A
IARC Volume
(VOL. 77; 2000)
IARC Notes
—
List
As per other sources

List generated from dn_risc_sustancias_cancer_otras

Category
G-A3, N-2, CP
Source
ACGIH, NTP, CP65
List
Carcinogens and mutagens (IARC) ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group
Grupo 2A
IARC Volume
(VOL. 77; 2000)
IARC Notes
—
List
Carcinogens (other sources) ?

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Category
G-A3, N-2, CP
Source
ACGIH, NTP, CP65
List
Breast cancer ?

Substances classified with H362 phrase (may cause harm to breast-fed children). Toxic for reproduction due to effects on lactation or due to transmissibility through breast milk.

Source
http://sciencereview.silentspring.org/mamm_detail.cfm?cid=556-52-5
List
Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect
—
Level
2
Source
—
List
Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

OEL Data
—
List
Prohibited for pregnant workers

Substances prohibited for pregnant workers

List
Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

List
Reproductive toxicants ?

Substances classified as toxic for reproduction under Regulation 1272/2008

List

Environmental regulations

Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

List

Restriction/prohibition regulations

Restricted substances REACH ?

Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.

Notes

Limitations:
Without prejudice to the other parts of this Annex the following shall apply to entries 28 to 30: 1. Shall not be placed on the market, or used,
- as substances,
- as constituents of other substances, or,
- in mixtures, for supply to the general public when the individual concentration in the substance or mixture is equal to or greater than:
- either the relevant specific concentration limit specified in Part 3 of Annex VI to Regulation (EC) No 1272/2008, or,
- the relevant concentration specified in Directive 1999/45/EC where no specific concentration limit is set out in Part 3 of Annex VI to Regulation (EC) No 1272/2008.
Without prejudice to the implementation of other Community provisions relating to the classification, packaging and labelling of substances and mixtures, suppliers shall ensure before the placing on the market that the packaging of such substances and mixtures is marked visibly, legibly and indelibly as follows: ‘Restricted to professional users’.
2. By way of derogation, paragraph 1 shall not apply to:
(a) medicinal or veterinary products as defined by Directive 2001/82/EC and Directive 2001/83/ EC;
(b) cosmetic products as defined by Directive 76/ 768/EEC;
(c) the following fuels and oil products:
- motor fuels which are covered by Directive 98/70/EC,
- mineral oil products intended for use as fuel in mobile or fixed combustion plants,
- fuels sold in closed systems (e.g. liquid gas bottles); (d) artists’ paints covered by Directive 1999/45/ EC;
(e) the substances listed in Appendix 11, column 1, for the applications or uses listed in Appendix 11, column 2. Where a date is specified in column 2 of Appendix 11, the derogation shall apply until the said date.

Source: Regulation 1907/2006 (REACH). Annex XVII

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