RISCTOX

RISCTOX Database

Search and consult detailed information about specific chemical substances.

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Identification

Name:
2,4-dinitrotoluene@2,4-DNT
Synonyms:
  • dinitrotolueno, grado tecnico [1]
CAS:
121-14-2
EC/EINECS:
204-450-0
Molecular Formula:
C7H6N2O4
International Chemical Safety Card (ICSC):
0727

Black list

Substances particularly hazardous to the environment or health

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS06

    Acute toxicity (oral, dermal, inhalation)

  • GHS08

    Respiratory sensitisation

  • GHS09

    Hazardous to the aquatic environment

H Phrases

  • H350 : May cause cancer

    Carc. (Cat. 1B) : Carcinogenicity

  • H341 : Suspected of causing genetic defects

    Muta. (Cat. 2) : Germ cell mutagenicity

  • H361f*** : Suspected of damaging fertility.

    Repr. (Cat. 2) : Reproductive toxicity

  • H331 : Toxic if inhaled

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H311 : Toxic in contact with skin

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H301 : Toxic if swallowed

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H373** : May cause damage to organs through prolonged or repeated exposure

    STOT RE (Cat. 2 *) : Specific target organ toxicity - repeated exposure

  • H400 : Very toxic to aquatic life

    Aquatic Acute (Cat. 1) : Hazardous to the aquatic environment

  • H410 : Very toxic to aquatic life with long lasting effects

    Aquatic Chronic (Cat. 1) : Hazardous to the aquatic environment

Specific health risks

As per IARC ?

Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.

IARC Group
GRUPO 2B
IARC Volume
(VOL. 65; 1996)
IARC Notes
—
List
As per other sources

List generated from dn_risc_sustancias_cancer_otras

Category
CP
Source
CP65
List
Carcinogens and mutagens (IARC) ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group
Grupo 2B
IARC Volume
(VOL. 65; 1996)
IARC Notes
—
List
Carcinogens (other sources) ?

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Category
CP
Source
CP65
List
Breast cancer ?

Substances classified with H362 phrase (may cause harm to breast-fed children). Toxic for reproduction due to effects on lactation or due to transmissibility through breast milk.

Source
http://sciencereview.silentspring.org/mamm_detail.cfm?cid=121-14-2
List
Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect
INESPECÍFICO
Level
1
Source
21
List
Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.

OEL Data
—
List
Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

List
Reproductive toxicants ?

Substances classified as toxic for reproduction under Regulation 1272/2008

List

Specific environmental risks

Persistent bioaccumulative and toxic ?

Substances identified as Persistent, Bioaccumulative and Toxic (PBT) according to the criteria of Annex XIII of the REACH Regulation. They pose a special risk of accumulation in the environment and in the food chain.

Sources
OSPAR
Link
http://www.ospar.org/v_substances/get_page.asp?v1=121142.xls
List

Environmental regulations

Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

List

Restriction/prohibition regulations

Restricted substances REACH ?

Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.

Notes

Limitations:
Without prejudice to the other parts of this Annex the following shall apply to entries 28 to 30: 1. Shall not be placed on the market, or used,
- as substances,
- as constituents of other substances, or,
- in mixtures, for supply to the general public when the individual concentration in the substance or mixture is equal to or greater than:
- either the relevant specific concentration limit specified in Part 3 of Annex VI to Regulation (EC) No 1272/2008, or,
- the relevant concentration specified in Directive 1999/45/EC where no specific concentration limit is set out in Part 3 of Annex VI to Regulation (EC) No 1272/2008.
Without prejudice to the implementation of other Community provisions relating to the classification, packaging and labelling of substances and mixtures, suppliers shall ensure before the placing on the market that the packaging of such substances and mixtures is marked visibly, legibly and indelibly as follows: ‘Restricted to professional users’.
2. By way of derogation, paragraph 1 shall not apply to:
(a) medicinal or veterinary products as defined by Directive 2001/82/EC and Directive 2001/83/ EC;
(b) cosmetic products as defined by Directive 76/ 768/EEC;
(c) the following fuels and oil products:
- motor fuels which are covered by Directive 98/70/EC,
- mineral oil products intended for use as fuel in mobile or fixed combustion plants,
- fuels sold in closed systems (e.g. liquid gas bottles); (d) artists’ paints covered by Directive 1999/45/ EC;
(e) the substances listed in Appendix 11, column 1, for the applications or uses listed in Appendix 11, column 2. Where a date is specified in column 2 of Appendix 11, the derogation shall apply until the said date.

Source: Regulation 1907/2006 (REACH). Annex XVII

List
Substances under evaluation. PACT ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State
—
Activity
—
Last update
—
Scope
—
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Substances subject to REACH authorization ?

Substances listed in Annex XIV of the REACH Regulation, subject to the prior authorisation scheme. To use them after the sunset date, companies must obtain authorisation from ECHA, demonstrating adequate risk control or the absence of viable alternatives.

List
Reach Candidates ?

Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.

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