RISCTOX Database
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Identification
- Name:
- 4,4'-methylenedianiline@MDA@ 4, 4´-MDA@
- Name (English):
- 4,4'-methylenedianiline@MDA@ 4, 4´-MDA@
- Synonyms:
-
- 4,4'-diaminodifenilmetano
- 4,4´-metilenodianilina
- CAS:
- 101-77-9
- EC/EINECS:
- 202-974-4
- Molecular Formula:
- C13H14N2
- International Chemical Safety Card (ICSC):
- 1111
- Uses:
- foaming agent resin
Black list
Substances particularly hazardous to the environment or health
CLASSIFICATION AND LABELLING (Regulation 1272/2008)
Symbols
-
Acute toxicity (oral, dermal, inhalation
-
Respiratory sensitisation
-
Hazardous to the aquatic environment
H Phrases
-
H350 : May cause cancer
Carc. (Cat. 1B) : Carcinogenicity
-
H341 : Suspected of causing genetic defects
Muta. (Cat. 2) : Germ cell mutagenicity
-
H370 ** : Causes damage to organs
STOT SE (Cat. 1) : Specific target organ toxicity - single exposure
-
H373 ** : May cause damage to organs through prolonged or repeated exposure
STOT RE (Cat. 2 *) : Specific target organ toxicity - repeated exposure
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H317 : May cause an allergic skin reaction
Skin Sens. (Cat. 1) : Respiratory/skin sensitization
-
H411 : Toxic to aquatic life with long lasting effects
Aquatic Chronic (Cat. 2) : Hazardous to the aquatic environment
Specific health risks
As per IARC ?
Substances classified by the International Agency for Research on Cancer (IARC/WHO) according to their evidence of carcinogenicity in humans. Groups range from 1 (proven human carcinogen) to 4 (probably not carcinogenic to humans). The IARC classification is an international reference in occupational and environmental health.
As per other sources
List generated from dn_risc_sustancias_cancer_otras
Carcinogens and mutagens (IARC) ?
Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.
Carcinogens (other sources) ?
Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.
Neurotoxic substances ?
Occupational Exposure Limits (OEL) ?
Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period.
Environmental regulations
Major accident hazards (Seveso) ?
Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.
ListRestriction/prohibition regulations
Restricted substances REACH ?
Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.
Limitations:
Without prejudice to the other parts of this Annex the following shall apply to entries 28 to 30: 1. Shall not be placed on the market, or used,
- as substances,
- as constituents of other substances, or,
- in mixtures, for supply to the general public when the individual concentration in the substance or mixture is equal to or greater than:
- either the relevant specific concentration limit specified in Part 3 of Annex VI to Regulation (EC) No 1272/2008, or,
- the relevant concentration specified in Directive 1999/45/EC where no specific concentration limit is set out in Part 3 of Annex VI to Regulation (EC) No 1272/2008.
Without prejudice to the implementation of other Community provisions relating to the classification, packaging and labelling of substances and mixtures, suppliers shall ensure before the placing on the market that the packaging of such substances and mixtures is marked visibly, legibly and indelibly as follows: ‘Restricted to professional users’.
2. By way of derogation, paragraph 1 shall not apply to:
(a) medicinal or veterinary products as defined by Directive 2001/82/EC and Directive 2001/83/ EC;
(b) cosmetic products as defined by Directive 76/ 768/EEC;
(c) the following fuels and oil products:
- motor fuels which are covered by Directive 98/70/EC,
- mineral oil products intended for use as fuel in mobile or fixed combustion plants,
- fuels sold in closed systems (e.g. liquid gas bottles); (d) artists’ paints covered by Directive 1999/45/ EC;
(e) the substances listed in Appendix 11, column 1, for the applications or uses listed in Appendix 11, column
2. Where a date is specified in column 2 of Appendix 11, the derogation shall apply until the said date.
Source: Regulation 1907/2006 (REACH). Annex XVII
Substances under evaluation. PACT ?
Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).
Substances subject to REACH authorization ?
Substances listed in Annex XIV of the REACH Regulation, subject to the prior authorisation scheme. To use them after the sunset date, companies must obtain authorisation from ECHA, demonstrating adequate risk control or the absence of viable alternatives.
ListReach Candidates ?
Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.
List