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RISCTOX Database

Search and consult detailed information about specific chemical substances.

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Identification

Name:
1,4-dioxane
Synonyms:
  • dioxido de etileno
  • dioxano
CAS:
123-91-1
EC/EINECS:
204-661-8
Molecular Formula:
C4H8O2
International Chemical Safety Card (ICSC):
0041
Uses:
solvent

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS02

    Flammable gases

  • GHS07

    Acute toxicity (oral, dermal, inhalation

  • GHS08

    Respiratory sensitisation

Signal word

Danger

H Phrases

  • H225 : Highly flammable liquid and vapour

    Flam. Liq. (Cat. 2) : Flammable liquid

  • H350 : May cause cancer

    Carc. (Cat. 1B) : Carcinogenicity

  • H335 : May cause respiratory irritation

    STOT SE (Cat. 3) : Specific target organ toxicity - single exposure

  • H319 : Causes serious eye irritation

    Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation

  • EUH019

  • EUH066

Specific health risks

Breast cancer ?

Substances classified with H362 phrase (may cause harm to breast-fed children). Toxic for reproduction due to effects on lactation or due to transmissibility through breast milk.

Source

http://sciencereview.silentspring.org/mamm_detail.cfm?cid=123-91-1

List
Carcinogens (other sources) ?

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Category

G-A3, N-2, CP

Source

ACGIH, NTP, CP65

List
Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect
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Level

2

Source
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According to IARC ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group

Grupo 2B

IARC Volume

(VOL. 11, SUPL. 7, VOL. 71; 1999)

IARC Notes
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Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)

OEL Data

VLA-ED: 7,3 mg/m3; 2ppm

VLA-EC: 73 mg/m3; 20 ppm

Posible contribución importante a la carga corporal total por exposición dérmica.

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Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

List

Restriction/prohibition regulations

REACH Candidates ?

Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.

List
Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

List
Substances under PACT evaluation ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State
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Activity
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Last update
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Scope
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