RISCTOX Database
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Identification
- Name:
- N-methyl-2-pyrrolidone@1-methyl-2-pyrrolidone
- Synonyms:
-
- 1-metil-2-pirrolidona
- CAS:
- 872-50-4
- EC/EINECS:
- 212-828-1
- Molecular Formula:
- C5H9NO
- International Chemical Safety Card (ICSC):
- 0513
- Uses:
- pesticide adhesive solvent additive hydrotropic agent
CLASSIFICATION AND LABELLING (Regulation 1272/2008)
Symbols
-
Acute toxicity (oral, dermal, inhalation
-
Respiratory sensitisation
Signal word
DangerH Phrases
-
H335 : May cause respiratory irritation
STOT SE (Cat. 3) : Specific target organ toxicity - single exposure
-
H315 : Causes skin irritation
Skin Irrit. (Cat. 2) : Skin corrosion/irritation
-
H319 : Causes serious eye irritation
Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation
-
H360D : May damage the unborn child.
Repr. (Cat. 1B) : Reproductive toxicity
Labelling
| Concentration | Labelling |
|---|---|
| C >= 5 % | Repr. Cat. 2; R61 |
| C >= 10 % | Xi; R36/37/38 |
| C = 10 % | STOT única, 3; H335 |
Specific health risks
Occupational Exposure Limits (OEL) ?
Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)
VLA-ED
10 ppm
40 mg/m3
VLA-EC
20 ppm
80 mg/m3
Posible contribución importante a la carga corporal total por exposición dérmica
Biological Exposure Indices (BEI) ?
Biological limit values (VLB) published by the Spanish National Institute of Safety and Health at Work (INSST). Reference values for assessing the risk of chemical agents by measuring them or their metabolites in biological matrices (blood, urine, exhaled air) of exposed workers.
IB:2-hidroxi-N-metilsuccinimida en orina
20 mg/g creatinina
IB: 5-hidroxi-N-metil-2-pirrolidona en Orina
70 mg/g creatinin
Prohibited for pregnant workers
Substances prohibited for pregnant workers
ListSpecific environmental risks
Volatile organic compounds ?
Volatile Organic Compounds (VOCs) regulated by Directive 1999/13/EC on the limitation of VOC emissions from certain activities, and by Royal Decrees 117/2003 and 227/2006. Substances contributing to tropospheric ozone formation that are subject to emission limits in industrial activities.
ListEnvironmental regulations
LPCIC (EPER)
Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).
false
true
false
Restriction/prohibition regulations
Restricted substances under REACH ?
Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.
1. Shall not be placed on the market after 1 November 2020 in any of the following: (a) clothing or related accessories; (b) textiles other than clothing which, under normal or reasonably foreseeable conditions of use, come into contact with human skin to an extent similar to clothing; (c) footwear; if the clothing, related accessory, textile other than clothing or footwear is for use by consumers and the substance is present in a concentration, measured in homogeneous material, equal to or greater than that specified for that substance in Appendix 12. 2. By way of derogation, in relation to the placing on the market of formaldehyde [CAS No 50-00-0] in jackets, coats or upholstery, the relevant concentration for the purposes of paragraph 1 shall be 300 mg/kg during the period between 1 November 2020 and 1 November 2023. The concentration specified in Appendix 12 shall apply thereafter. 3. Paragraph 1 shall not apply to: (a) clothing, related accessories or footwear, or parts of clothing, related accessories or footwear, made exclusively of natural leather, fur or hide; (b) non-textile fasteners and non-textile decorative attachments; (c) second-hand clothing, related accessories, textiles other than clothing or footwear (d) wall-to-wall carpets and textile floor coverings for indoor use, rugs and runners. 4. Paragraph 1 shall not apply to clothing, related accessories, textiles other than clothing, or footwear within the scope of Regulation (EU) 2016/425 of the European Parliament and of the Council1 or Regulation (EU) 2017/745 of the European Parliament and of the Council2. 5. Paragraph 1(b) shall not apply to disposable textiles. ‘Disposable textiles’ means textiles that are designed to be used only once or for a limited time and are not intended for subsequent use for the same or a similar purpose. 6. Paragraphs 1 and 2 shall apply without prejudice to the application of any stricter restrictions set out in this Annex or in other applicable Union legislation. 7. The Commission shall review the exemption in paragraph 3(d) and, if appropriate, modify that point accordingly.
REACH Candidates ?
Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.
ListSubstances under PACT evaluation ?
Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).
Comission
RMOA
CMR