ETUI – European Trade Union Institute Fundación 1º de Mayo
ISTAS – Institut Sindical de Treball, Ambient i Salut

RISCTOX Database

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Identification

Name:
1,4,5,8-tetraaminoanthraquinone
Synonyms:
  • AZUL DISPERSO 1
  • COLORANTE DISPERSO
  • CI 64500
  • AZUL DE DISPERSION 1
  • 1,4,5,8-TETRAMINOANTRAQUINONA
CAS:
2475-45-8
EC/EINECS:
219-603-7
Molecular Formula:
C14H12N4O2

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS05

    Corrosive to metals

  • GHS07

    Acute toxicity (oral, dermal, inhalation

  • GHS08

    Respiratory sensitisation

Signal word

Danger

H Phrases

  • H350 : May cause cancer

    Carc. (Cat. 1B) : Carcinogenicity

  • H315 : Causes skin irritation

    Skin Irrit. (Cat. 2) : Skin corrosion/irritation

  • H318 : Causes serious eye damage

    Eye Dam. (Cat. 1) : Serious eye damage/eye irritation

  • H317 : May cause an allergic skin reaction

    Skin Sens. (Cat. 1) : Respiratory/skin sensitization

Specific health risks

Carcinogens (other sources) ?

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Category
N-2, CP
Source
NTP, CP65
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Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect
—
Level
2
Source
—
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According to IARC ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group
Grupo 2B
IARC Volume
(VOL. 48; 1990)
IARC Notes
—
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Prohibited for breastfeeding workers ?

Chemical agents whose exposure is prohibited for breastfeeding workers under Royal Decree 298/2009 and Directive 92/85/EEC. Includes substances that may be transmitted through breast milk or that negatively affect milk production.

Comment
—
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Prohibited for pregnant workers ?

Chemical agents whose exposure is prohibited for pregnant workers under Royal Decree 298/2009 (amendment of RD 39/1997) and Directive 92/85/EEC. Includes substances with proven risk of foetal harm, miscarriage or pregnancy complications.

Comment
—
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Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

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Sensitisers ?

Substances with skin or respiratory sensitisation potential

List

Restriction/prohibition regulations

Restricted substances under REACH ?

Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.

Notes
1. Shall not be placed on the market after 1 November 2020 in any of the following:
(a) clothing or related accessories;
(b) textiles other than clothing which, under normal or reasonably foreseeable conditions of use, come into contact with human skin to an extent similar to clothing;
(c) footwear;
if the clothing, related accessory, textile other than clothing or footwear is for use by consumers and the substance is present in a concentration, measured in homogeneous material, equal to or greater than that specified for that substance in Appendix 12.
2. By way of derogation, in relation to the placing on the market of formaldehyde [CAS No 50-00-0] in jackets, coats or upholstery, the relevant concentration for the purposes of paragraph 1 shall be 300 mg/kg during the period between 1 November 2020 and 1 November 2023. The concentration specified in Appendix 12 shall apply thereafter.
3. Paragraph 1 shall not apply to:
(a) clothing, related accessories or footwear, or parts of clothing, related accessories or footwear, made exclusively of natural leather, fur or hide;
(b) non-textile fasteners and non-textile decorative attachments;
(c) second-hand clothing, related accessories, textiles other than clothing or footwear
(d) wall-to-wall carpets and textile floor coverings for indoor use, rugs and runners.
4. Paragraph 1 shall not apply to clothing, related accessories, textiles other than clothing, or footwear within the scope of Regulation (EU) 2016/425 of the European Parliament and of the Council1 or Regulation (EU) 2017/745 of the European Parliament and of the Council2.
5. Paragraph 1(b) shall not apply to disposable textiles. ‘Disposable textiles’ means textiles
that are designed to be used only once or for a limited time and are not intended for subsequent use for the same or a similar purpose.
6. Paragraphs 1 and 2 shall apply without prejudice to the application of any stricter restrictions set out in this Annex or in other applicable Union legislation.
7. The Commission shall review the exemption in paragraph 3(d) and, if appropriate, modify
that point accordingly.
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Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

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