RISCTOX Database
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Identification
- Name:
- 2-methyl-m-phenylene diisocyanate@ Toluene-2,4-di-isocyanate@ 4-methyl-m-phenylene diisocyanate@ Toluene-2,6-di-isocyanate@ m-tolylidene diisocyanate@ Toluene-diisocyanate
- Synonyms:
-
- Diisocianato de 2-metil-m-fenileno
- Diisocianato de tolueno
- Diisocianato de 4-metil-m-fenileno
- 2,6-diisocianato de tolueno
- 2,4-diisocianato de tolueno
- Diisocianato de m-tolilideno
- CAS:
- 91-08-7
- EC/EINECS:
- 202-039-0
- Molecular Formula:
- C9H6N2O2
- International Chemical Safety Card (ICSC):
- 1301
- Uses:
- hardener paint additive
Black list
Substances particularly hazardous to the environment or health
CLASSIFICATION AND LABELLING (Regulation 1272/2008)
Symbols
-
Acute toxicity (oral, dermal, inhalation)
-
Respiratory sensitisation
Signal word
DangerH Phrases
-
H351 : Suspected of causing cancer
Carc. (Cat. 2) : Carcinogenicity
-
H330 : Fatal if inhaled
Acute Tox. (Cat. 2 *) : Acute toxicity
-
H319 : Causes serious eye irritation
Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation
-
H335 : May cause respiratory irritation
STOT SE (Cat. 3) : Specific target organ toxicity - single exposure
-
H315 : Causes skin irritation
Skin Irrit. (Cat. 2) : Skin corrosion/irritation
-
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled
Resp. Sens. (Cat. 1) : Respiratory/skin sensitization
-
H317 : May cause an allergic skin reaction
Skin Sens. (Cat. 1) : Respiratory/skin sensitization
-
H412 : Harmful to aquatic life with long lasting effects
Aquatic Chronic (Cat. 3) : Hazardous to the aquatic environment
Notes
- R.1272-Note C
Labelling
| Concentration | Labelling |
|---|---|
| C >= 0,1 % | R42 |
| C >= 0,1 % | Sens. resp., 1; H334 |
Specific health risks
Carcinogens (other sources) ?
Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.
Neurotoxic substances ?
According to IARC ?
Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.
Occupational Exposure Limits (OEL) ?
Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)
Restriction/prohibition regulations
REACH sensitisers ?
Substances identified as respiratory or skin sensitisers under the REACH Regulation. Includes substances that, without necessarily having a CLP classification, have been assessed by ECHA as potentially allergenic in occupational exposure contexts.
ListRestricted substances under REACH ?
Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.
2. 2. Shall not be placed on the market as substances on their own, as a constituent in other substances or in mixtures for industrial and professional use(s) after 24 February 2022, unless: (a) the concentration of diisocyanates individually and in combination is less than 0,1 % by weight, or
(b) the supplier ensures that the recipient of the substance(s) or mixture(s) is provided with information on the requirements referred to in point (b) of paragraph 1 and the following statement is placed on the packaging, in a manner that is visibly distinct from the rest of the label information: “As from 24 August 2023 adequate training is required before industrial or professional use”.
3. For the purpose of this entry “industrial and professional user(s)” means any worker or self-employed worker handling diisocyanates on their own, as a constituent in other substances or in mixtures for industrial and professional use(s) or supervising these tasks.
4. The training referred to in point (b) of paragraph 1 shall include the instructions for the control of dermal and inhalation exposure to diisocyanates at the workplace without prejudice to any national occupational exposure limit value or other appropriate risk management measures at national level. Such training shall be conducted by an expert on occupational safety and health with competence acquired by relevant vocational training. That training shall cover as a minimum:
(a) the training elements in point (a) of paragraph 5 for all industrial and professional use(s). (b) the training elements in points (a) and
(b) of paragraph 5 for the following uses:
- handling open mixtures at ambient temperature (including foam tunnels);
— spraying in a ventilated booth;
— application by roller;
— application by brush;
— application by dipping and pouring;
— mechanical post treatment (e.g. cutting) of not fully cured articles which are not warm anymore;
— cleaning and waste;
— any other uses with similar exposure through the dermal and/or inhalation route; (c) the training elements in points (a), (b) and (c) of paragraph 5 for the following uses: — handling incompletely cured articles (e.g. freshly cured, still warm);
— foundry applications; — maintenance and repair that needs access to equipment; — open handling of warm or hot formulations (> 45 °C);
— spraying in open air, with limited or only natural ventilation (includes large industry working halls) and spraying with high energy (e.g. foams, elastomers);
— and any other uses with similar exposure through the dermal and/or inhalation route.
5. Training elements:
(a) general training, including on-line training, on:
— chemistry of diisocyanates;
— toxicity hazards (including acute toxicity);
— exposure to diisocyanates;
— occupational exposure limit values;
— how sensitisation can develop;
— odour as indication of hazard;
— importance of volatility for risk;
— viscosity, temperature, and molecular weight of diisocyanates;
— personal hygiene;
— personal protective equipment needed, including practical instructions for its correct use and its limitations;
— risk of dermal contact and inhalation exposure;
— risk in relation to application process used;
— skin and inhalation protection scheme;
— ventilation;
— cleaning, leakages, maintenance;
— discarding empty packaging;
— protection of bystanders;
— identification of critical handling stages;
— specific national code systems (if applicable);
— behaviour-based safety;
— certification or documented proof that training has been successfully completed
(b) intermediate level training, including on-line training, on:
— additional behaviour-based aspects;
— maintenance;
— management of change;
— evaluation of existing safety instructions;
— risk in relation to application process used;
— certification or documented proof that training has been successfully completed
(c) advanced training, including on-line training, on:
— any additional certification needed for the specific uses covered;
— spraying outside a spraying booth;
— open handling of hot or warm formulations (> 45 °C);
— certification or documented proof that training has been successfully completed
6. The training shall comply with the provisions set by the Member State in which the industrial or professional user(s) operate. Member States may implement or continue to apply their own national requirements for the use of the substance(s) or mixture(s), as long as the minimum requirements set out in paragraphs 4 and 5 are met.
7. The supplier referred to in point (b) of paragraph 2 shall ensure that the recipient is provided with training material and courses pursuant to paragraphs 4 and 5 in the official language(s) of the Member State(s) where the substance(s) or mixture(s) are supplied. The training shall take into consideration the specificity of the products supplied, including composition, packaging, and design.
8. The employer or self-employed shall document the successful completion of the training referred to in paragraphs 4 and 5. The training shall be renewed at least every five years.
9. Member States shall include in their reports pursuant to Article 117(1) the following information:
a) any established training requirements and other risk management measures related to the industrial and professional uses of diisocyanates foreseen in national law;
(b) the number of cases of reported and recognised occupational asthma and occupational respiratory and dermal diseases in relation to diisocyanates;
(c) national exposure limits for diisocyanates, if there are any;
(d) information about enforcement activities related to this restriction.
10. This restriction shall apply without prejudice to other Union legislation on the protection of safety and health of workers at the workplace.
Major accident hazards (Seveso) ?
Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.
ListSubstances under PACT evaluation ?
Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).