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RISCTOX Database

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Identification

Name:
N,N-dimethylformamide
Synonyms:
  • dimetilformamida
CAS:
68-12-2
EC/EINECS:
200-679-5
Molecular Formula:
C3H7NO
International Chemical Safety Card (ICSC):
0457
Uses:
solvent

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS07

    Acute toxicity (oral, dermal, inhalation

  • GHS08

    Respiratory sensitisation

Signal word

Danger

H Phrases

  • H332 : Harmful if inhaled

    Acute Tox. (Cat. 4 *) : Acute toxicity

  • H312 : Harmful in contact with skin

    Acute Tox. (Cat. 4 *) : Acute toxicity

  • H319 : Causes serious eye irritation

    Eye Irrit. (Cat. 2) : Serious eye damage/eye irritation

  • H360D : May damage the unborn child.

    Repr. (Cat. 1B) : Reproductive toxicity

Specific health risks

Endocrine disruptors ?

Substances with endocrine disrupting activity

Disruptor level

UE2

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Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect

SNC

Level

1

Source

17, 24

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According to IARC ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group

Grupo 3

IARC Volume

(VOL. 47; VOL. 71; 1999)

IARC Notes
—
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Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)

OEL Data

VLA-ED

15 mg/m3

5 ppm


VLA-EC

30 mg/m3

10 ppm


Posible contribución importante a la carga corporal total por exposición dérmica



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Biological Exposure Indices (BEI) ?

Biological limit values (VLB) published by the Spanish National Institute of Safety and Health at Work (INSST). Reference values for assessing the risk of chemical agents by measuring them or their metabolites in biological matrices (blood, urine, exhaled air) of exposed workers.

BEI Data

IB: N-Metilformamida en orina

15 mg/l


IB: N-Acetil-S-(N- metilcarbamoil)cisteína en Orina

40 mg/l


Notas: S

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Prohibited for pregnant workers

Substances prohibited for pregnant workers

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Reproductive toxicants ?

Substances classified as toxic for reproduction under Regulation 1272/2008

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Restriction/prohibition regulations

Restricted substances under REACH ?

Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.

Notes

1. Shall not be placed on the market as a substance on its own, as a constituent of other substances, or in mixtures in a concentration equal to or greater than 0,3 % after 12 December 2023 unless manufacturers, importers and downstream users have included in the relevant chemical safety reports and safety data sheets, Derived No-Effect Levels (DNELs) relating to exposure of workers of 6 mg/m3 for exposure by inhalation and 1,1 mg/kg/day for dermal exposure. 2. Shall not be manufactured, or used, as a substance on its own, as a constituent of other substances, or in mixtures in a concentration equal to or greater than 0,3 % after 12 December 2023 unless manufacturers and downstream users take the appropriate risk management measures and provide the appropriate operational conditions to ensure that exposure of workers is below the DNELs specified in paragraph 1. 3. By way of derogation from paragraphs 1 and 2, the obligations laid down therein shall apply from 12 December 2024 in relation to placing on the market for use, or use, as a solvent in direct or transfer polyurethane coating processes of textiles and paper material or the production of polyurethane membranes, and from 12 December 2025 in relation to placing on the market for use, or use, as a solvent in the dry and wet spinning processes of synthetic fibres.

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REACH Candidates ?

Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.

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Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

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Substances under PACT evaluation ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State

Commission

Activity

RMOA

Last update
2018-10-25T00:00:00
Scope

CMR

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