Substances classified with H362 phrase (may cause harm to breast-fed children). Toxic for reproduction due to effects on lactation or due to transmissibility through breast milk.

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Substances with endocrine disrupting activity

Substances with neurotoxic effects

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

Substances identified as soil contaminants under Spanish and European environmental regulations. Includes substances capable of persisting in soil, bioaccumulating in the terrestrial food chain, and affecting soil ecosystems and groundwater.

Substances subject to atmospheric emission limitations under the Industrial Emissions Directive (2010/75/EU) and its Spanish transposition. Includes pollutants regulated in industrial installation emission permits and best available technique reference documents (BAT/BREF).

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).