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ethylene oxide, oxirane@ethylene oxide@Dimethylene oxide@1,2-Epoxy ethane@Oxirane

Identification RD1272 Classification Health risks Environmental risks Env. regulations Restrictions PDF

Identification

Name:
ethylene oxide, oxirane@ethylene oxide@Dimethylene oxide@1,2-Epoxy ethane@Oxirane
Synonyms:
  • oxirano
CAS:
75-21-8
EC/EINECS:
200-849-9
Molecular Formula:
C2H4O
International Chemical Safety Card (ICSC):
0155
Uses:
solvent additive emulsifier pesticide fumigant sterilizer

CLASSIFICATION AND LABELLING (Regulation 1272/2008)

Symbols

  • GHS02

    Flammable gases

  • GHS04

    Gases under pressure

  • GHS06

    Acute toxicity (oral, dermal, inhalation)

  • GHS08

    Respiratory sensitisation

Signal word

Danger

H Phrases

  • H350 : May cause cancer

    Gas a pres.,

  • H220 : Extremely flammable gas

    Flam. Gas (Cat. 1) : Flammable gas

  • H340 : May cause genetic defects

    Carc. (Cat. 1B) : Carcinogenicity

  • H360Fd : May damage fertility. Suspected of damaging the unborn child.

    Muta. (Cat. 1B) : Germ cell mutagenicity

  • H331 : Toxic if inhaled

    Repr. (Cat. 1B) : Reproductive toxicity

  • H301 : Toxic if swallowed

    Acute Tox. (Cat. 3 *) : Acute toxicity

  • H335 : May cause respiratory irritation

    Acute Tox. (Cat. 3) : Acute toxicity

  • H336 : May cause drowsiness or dizziness

    STOT SE, 3

  • H372 : Causes damage to organs through prolonged or repeated exposure

    STOT SE, 3

  • H372 : Causes damage to organs through prolonged or repeated exposure

    STOT RE, 1

  • H314 : Causes severe skin burns and eye damage

    Corro. piel, 1

  • H318 : Causes serious eye damage

    Daño ocular, 1

Notes

  • R.1272-Note U

Specific health risks

According to IARC ?

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

IARC Group

Grupo 1

IARC Volume

(VOL. 97, 100F; 2012)

IARC Notes

Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

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Carcinogens (other sources) ?

Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Category

G-A2, N-1, CP

Source

ACGIH, NTP, CP65

List
Breast cancer ?

Substances classified with H362 phrase (may cause harm to breast-fed children). Toxic for reproduction due to effects on lactation or due to transmissibility through breast milk.

Source

http://sciencereview.silentspring.org/mamm_detail.cfm?cid=75-21-8

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Neurotoxic substances ?

Substances with neurotoxic effects

Neurotoxic effect

SNC

Level

4

Source

14

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Occupational Exposure Limits (OEL) ?

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)

OEL Data

1.8 mg/m3

1 ppm

Posible contribución importante a la carga corporal total por exposición dérmica

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Prohibited for pregnant workers

Substances prohibited for pregnant workers

List
Carcinogens and mutagens (Regulation 1272/2008) ?

Substances classified as carcinogenic or mutagenic under Regulation 1272/2008

List
Reproductive toxicants ?

Substances classified as toxic for reproduction under Regulation 1272/2008

List

Specific environmental risks

Persistent bioaccumulative and toxic ?

Substances identified as Persistent, Bioaccumulative and Toxic (PBT) according to the criteria of Annex XIII of the REACH Regulation. They pose a special risk of accumulation in the environment and in the food chain.

Sources

REACH

Link

http://apps.echa.europa.eu/registered/data/dossiers/DISS-828df712-525d-186a-e044-00144fd73934/DISS-828df712-525d-186a-e044-00144fd73934_DISS-828df712-525d-186a-e044-00144fd73934.html

List
Volatile organic compounds ?

Volatile Organic Compounds (VOCs) regulated by Directive 1999/13/EC on the limitation of VOC emissions from certain activities, and by Royal Decrees 117/2003 and 227/2006. Substances contributing to tropospheric ozone formation that are subject to emission limits in industrial activities.

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Environmental regulations

LPCIC (EPER)

Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).

EPER Water

false

EPER Air

true

EPER Soil

true

List
EPER Air ?

Substances from List 2 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Pollutants that may affect surface and groundwater bodies and must be considered in the integrated environmental authorisation of industrial installations.

List
EPER Soil ?

Substances from List 3 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Substances present in waste generated by IPPC installations that must be controlled and minimised within the framework of best available techniques.

List

Restriction/prohibition regulations

Restricted substances under REACH ?

Substances listed in Annex XVII of the REACH Regulation (EC) No 1907/2006, subject to restrictions on their manufacture, placing on the market or use. Restrictions may be total or partial, limiting specific applications, maximum concentrations or user groups.

Notes

Limitations: Without prejudice to the other parts of this Annex the following shall apply to entries 28 to 30: 1. Shall not be placed on the market, or used, - as substances, - as constituents of other substances, or, - in mixtures, for supply to the general public when the individual concentration in the substance or mixture is equal to or greater than: - either the relevant specific concentration limit specified in Part 3 of Annex VI to Regulation (EC) No 1272/2008, or, - the relevant concentration specified in Directive 1999/45/EC where no specific concentration limit is set out in Part 3 of Annex VI to Regulation (EC) No 1272/2008. Without prejudice to the implementation of other Community provisions relating to the classification, packaging and labelling of substances and mixtures, suppliers shall ensure before the placing on the market that the packaging of such substances and mixtures is marked visibly, legibly and indelibly as follows: ‘Restricted to professional users’. 2. By way of derogation, paragraph 1 shall not apply to: (a) medicinal or veterinary products as defined by Directive 2001/82/EC and Directive 2001/83/ EC; (b) cosmetic products as defined by Directive 76/ 768/EEC; (c) the following fuels and oil products: - motor fuels which are covered by Directive 98/70/EC, - mineral oil products intended for use as fuel in mobile or fixed combustion plants, - fuels sold in closed systems (e.g. liquid gas bottles); (d) artists’ paints covered by Directive 1999/45/ EC; (e) the substances listed in Appendix 11, column 1, for the applications or uses listed in Appendix 11, column 2. Where a date is specified in column 2 of Appendix 11, the derogation shall apply until the said date.

Source: Regulation 1907/2006 (REACH). Annex XVII

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Substances under CoRAP evaluation ?

Substances included in the Community Rolling Action Plan (CoRAP) of the REACH Regulation. These are substances selected for evaluation by EU Member States due to indications of risk to human health or the environment, with the aim of clarifying whether regulatory action is warranted.

Year
2012
Member State

Austria

Initial grounds for concern

Human health/CMR; Exposure/High aggregated tonnage

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Substances under PACT evaluation ?

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).

Member State

NORWAY

Activity
—
Last update
2018-10-25T00:00:00
Scope
—
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Major accident hazards (Seveso) ?

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

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