Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Substances with endocrine disrupting activity

Substances with neurotoxic effects

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

Daily exposure limit values (VLA-ED) published by the Spanish National Institute of Safety and Health at Work (INSST). They represent the average concentration of a chemical agent in the worker's breathing zone, measured or calculated in a time-weighted manner for an 8-hour daily working period. (https://www.insst.es/valores-limites-de-exposicion)

Substances classified with chronic aquatic toxicity under the CLP Regulation (H410–H413 phrases, Aquatic Chronic categories 1 to 4). They pose a long-term hazard to aquatic organisms, even at low concentrations and through prolonged exposure.

Volatile Organic Compounds (VOCs) regulated by Directive 1999/13/EC on the limitation of VOC emissions from certain activities, and by Royal Decrees 117/2003 and 227/2006. Substances contributing to tropospheric ozone formation that are subject to emission limits in industrial activities.

Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).

Substances from List 2 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Pollutants that may affect surface and groundwater bodies and must be considered in the integrated environmental authorisation of industrial installations.

Substances included in the Community Rolling Action Plan (CoRAP) of the REACH Regulation. These are substances selected for evaluation by EU Member States due to indications of risk to human health or the environment, with the aim of clarifying whether regulatory action is warranted.

Hazardous substances listed in Annex I of the Seveso III Directive (Directive 2012/18/EU), transposed in Spain by Royal Decree 840/2015. Their presence in industrial establishments in quantities equal to or above established thresholds triggers obligations to implement major accident risk control measures.

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).