Substances classified as carcinogens or mutagens Category 3 under the Dangerous Preparations Directive criteria (pre-CLP). Substances with limited evidence or indications of carcinogenicity or mutagenicity.

Substances with endocrine disrupting activity

Substances with neurotoxic effects

Substances classified as carcinogens or mutagens Category 2 under the CLP Regulation (GHS), bearing H351 and/or H341 phrases. These are substances suspected of causing cancer or heritable genetic mutations in humans.

Substances identified as Persistent, Bioaccumulative and Toxic (PBT) according to the criteria of Annex XIII of the REACH Regulation. They pose a special risk of accumulation in the environment and in the food chain.

Substances classified with acute aquatic toxicity under the CLP Regulation (H400 phrase, Aquatic Acute 1). They present an immediate hazard to aquatic organisms, and their use or discharge can cause rapid damage to aquatic ecosystems.

Atmospheric pollutants that negatively affect air quality. Includes compounds contributing to tropospheric ozone formation, suspended particulate matter (PM), acid rain or other ambient air pollution phenomena.

Substances subject to atmospheric emission limitations under the Industrial Emissions Directive (2010/75/EU) and its Spanish transposition. Includes pollutants regulated in industrial installation emission permits and best available technique reference documents (BAT/BREF).

Priority substances and specific pollutants within the EU water policy framework, established by the Water Framework Directive (2000/60/EC) and the Priority Substances Directive (2008/105/EC and amendments). Substances posing significant risk to European surface waters and subject to Environmental Quality Standards (EQS).

Substances from List 1 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Atmospheric pollutants —including SO₂, NOx, heavy metals and organic compounds— that must be taken into account when setting emission limit values for IPPC installations.

Substances from List 2 of Annex III of the IPPC Directive (integrated into the Industrial Emissions Directive 2010/75/EU). Pollutants that may affect surface and groundwater bodies and must be considered in the integrated environmental authorisation of industrial installations.

Substances of Very High Concern (SVHC) identified by ECHA and included on the REACH Candidate List. These are substances with CMR, PBT, vPvB or endocrine disrupting properties liable to be included in Annex XIV (authorisation). Their inclusion generates notification obligations for articles containing them.

Substances under active regulatory monitoring through ECHA's PACT (Public Activities Coordination Tool). Allows tracking which regulatory authorities are examining a substance and what potential regulatory actions are being considered (restriction, SVHC identification, harmonised classification, etc.).